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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Endoplasmic reticulum stress and inflammation in the central nervous system

Fig. 1

The Adaptive Signals of the Mammalian UPR. The activation of PERK, IRE-1α and ATF6 in response to protein misfolding stress primarily requires the dissociation of the molecular chaperone GRP78 from each of the ER stress sensors. This initiates signaling cascades which orchestrate the transcriptional and translational landscape of the cell in an effort to maintain homeostasis

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