Fig. 2From: Endoplasmic reticulum stress and inflammation in the central nervous systemApoptotic Signals Associated with Chronic UPR Activation. Persistent ER stress triggers the apoptotic component of the UPR. PERK and IRE-1α drive UPR-induced apoptosis by initiating pathways which facilitate enhanced ROS production, Ca2+ dysregulation and caspase activationBack to article page