Fig. 2From: Late onset Alzheimer’s disease genetics implicates microglial pathways in disease riskEfferocytosis model of microglia in LOAD. Microglia contain multiple receptors that can recognize cellular distress signals and other ligands on apoptotic or necrotic cells, including lipids, C1q, and APOE. Propagation of downstream signals activate the transcription factor PU.1, which transcribes the majority of the genes involved in these pathwaysBack to article page