Table 1 AD-risk loci identified through genome-wide analyses (GWAS and GWAX) [24, 25]
From: Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
SNP | Chr | Reported gene | Additional genes in locus |
|---|---|---|---|
rs6656401 | 1 | CR1 | |
rs6733839 | 2 | BIN1 | |
rs35349669 | 2 | INPP5D | NGEF, NEU2 |
rs190982 | 5 | MEF2C | LOC645323, MIR9-2 |
rs2074612a | 5 | SCIMP | ZNF594, RABEP1, USP6 |
rs9271192 | 6 | HLA-DRB5– HLA-DRB1 | C6orf10, HLA-DRB5, HLA-DRB6, HLA-DRB1, HLA-DQA1, HCG23, BTNL2, HLA-DRA, HLA-DQB1, HLA-DQA2, HLA-DQB2, HLA-DOB, TAP1, TAP2, PSMB8, PSMB9 |
rs10948363 | 6 | CD2AP | GPR111, GPR115 |
rs2718058 | 7 | NME8 | GPR141 |
rs1476679 | 7 | ZCWPW1 | TRIM4, GJC3, AZGP1, AZGP1P1, ZKSCAN1, ZSCAN21, ZNF3, COPS6, MCM7, C7orf59, GPC2, STAG3, GATS, PVRIG, SPDYE3, PMS2P1, PILRA, PILRB, PPP1R35, MEPCE, NYAP1, SAP25, AGFG2, LRCH4, ZASP, LRCH4, FBXO24, PCOLCE-AS1 |
rs11771145 | 7 | EPHA1 | CLCN1, FAM131B, ZYX, TAS2R60, LOC285965, TAS2R41 |
rs28834970 | 8 | PTK2B | STMN4, TRIM35, CHRNA2, EPHX2 |
rs9331896 | 8 | CLU | PTK2B, CHRNA2, EPHX2, SCARA3, CCDC25, ESCO2, PBK |
rs7920721a | 10 | ECHDC3 | |
rs10838725 | 11 | CELF1 | ARFGAP2, PACSIN3, DDB2, ACP2, MADD, MYBPC3, SPI1, SLC39A13, PSMC3, RAPSN, PTPMT1, KBTBD4, NDUFS3, C1QTNF4, MTCH2, AGBL2, FNBP4, NUP160 |
rs983392 | 11 | MS4A6A | PLAC1L, MS4A3, MS4A2, MS4A4A, MS4A6E |
rs10792832 | 11 | PICALM | CCDC83 |
rs11218343 | 11 | SORL1 | |
rs17125944 | 14 | FERMT2 | ERO1L, PSMC6, STYX, GNPNAT1 |
rs10498633 | 14 | SLC24A4 | RIN3 |
rs59685680a | 15 | SPPL2A | TRPM7, USP50 |
rs77493189a | 17 | HBEGF | HBEGF |
rs4147929 | 19 | ABCA7 | CFD, MED16, PRTN3, R3HDM4, KISS1R, ELANE, ARID3A, TMEM259, GRIN3B, WDR18, HMHA1, CNN2, POLR2E, SBNO2, GPX4, ATP5D, MIDN, CIRBP, EFNA2 |
rs7274581 | 20 | CASS4 | CSTF1, RTFDC1, GCNT7, FAM209A, FAM209B |