Skip to main content
Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

Fig. 1

Microglia are depleted in CX 3 CR1-iDTR mice over 1–7 days after DT administration and repopulate within 2 weeks after DT administration. a. Timeline of tamoxifen administration, DT administration and analysis of microglia number. Microglia were examined by Iba1 staining before (D9), 1 day after (D13), 1 week after (D20) and 2 weeks after DT administration (D27). b. Coronal sections of the cortex stained for Iba1 from CX 3 CR1 CreER/+ and CX 3 CR1-iDTR mice on D9, D13, D20 and D27, respectively. Scale bar, 100 μm. c. Quantification of Iba1 positive cells showing that the majority of microglia were depleted in the first week after DT administration and ~50% of microglia were repopulated during the second week in CX 3 CR1-iDTR mice (n = 4, * P < 0.05, Mann-Whitney test)

Back to article page