TY - JOUR AU - Lee, Sang Hun AU - Lutz, David AU - Mossalam, Mohanad AU - Bolshakov, Vadim Y. AU - Frotscher, Michael AU - Shen, Jie PY - 2017 DA - 2017/06/15 TI - Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway JO - Molecular Neurodegeneration SP - 48 VL - 12 IS - 1 AB - Presenilins play a major role in the pathogenesis of Alzheimer’s disease, in which the hippocampus is particularly vulnerable. Previous studies of Presenilin function in the synapse, however, focused exclusively on the hippocampal Schaffer collateral (SC) pathway. Whether Presenilins play similar or distinct roles in other hippocampal synapses is unknown. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-017-0189-5 DO - 10.1186/s13024-017-0189-5 ID - Lee2017 ER -