Fig. 1

Impaired long-term potentiation at hippocampal MF synapses in PS cDKO mice. a Normal synaptic transmission in PS cDKO mice at 2 months of age. The synaptic input–output relationship was obtained by plotting the fiber volley (FV) amplitude against the initial slope of the evoked fEPSP. Each point represents data averaged across all slices for a narrow bin of FV amplitude. Right panel shows representative traces of fEPSPs evoked by various stimulation intensities. b Impaired LTP induced by 5 TBS in PS cDKO mice. Superimposed traces are averages of four consecutive responses 1 min before (thin line) and 50 min after (thick line) TBS induction. DCG IV (2 μM) was applied at the end of all experiments to confirm the recording of MF synapses. All data represent means ± SEM. The number of hippocampal slices (left) and mice (right) used in each experiment is indicated in parentheses