Fig. 2
Impaired short-term plasticity at hippocampal MF synapses in PS cDKO mice. a Representative traces of fEPSPs evoked by two consecutive stimuli with a 60 ms inter-stimulus interval. b Average PPF plotted as a function of the inter-stimulus intervals (20-2000 ms) shows reduced PPF in PS cDKO mice (F1, 17 = 14.71; p = 0.0013; two-way ANOVA). c Synaptic facilitation elicited by stimulus trains is impaired in a frequency-dependent manner in PS cDKO mice (1 Hz: F1, 13 = 11.64, p = 0.005; 5 Hz: F1, 13 = 13.33, p = 0.003; 10 Hz: F1, 15 = 9.67, p = 0.008; 20 Hz: F1, 15 = 9.71, p = 0.008; two-way ANOVA). fEPSP slopes shown are normalized to the slope of the first fEPSP of the stimulus train. All data represent means ± SEM (** p < 0.01; two-way ANOVA). The number of hippocampal slices (left) and mice (right) used in each experiment is indicated in parentheses