Table 3 Studies involving stress paradigms and Aβ production
From: Targeting psychologic stress signaling pathways in Alzheimer’s disease
Studies on Aβ | Model | Stress paradigm | Effect | Comments |
|---|---|---|---|---|
Kang et al. (2007) [47] | Tg2576 [82] | 3 months isolation | ↑ | |
Dong et al. (2008) [48] | Tg2576 | 6 months isolation | ↑ | |
Lee et al. (2009) [83] | Tg2576 | 2 h restraint daily for 16 days | ↑ | Measured ISF, soluble Aβ |
Ray et al. (2011) [50] | Wistar rat | 5 h restraint or bilateral UCN1 injection in amygdala | ↑ | |
Huang et al. (2011) [84] | APP/PS1 [85] | 4 months isolation | ↑ | |
Rothman et al. (2012) [86] | 3xTg AD [87] | Cage switched for 6 h/day for 2–3 days/week for 6 weeks | ↑ | |
Dong et al. (2012) [49] | Tg2576/ CRH overexpressing [88] | CRH overexpressing transgenic | ↑ | |
Rothman et al. (2013) [53] | 3xTg AD | 6 h sleep restriction for 6 weeks | - | Aβ and tau measures trending upward but non-significant |
Dong et al. (2014) [43] | Tg2576 | One week or 10 months of isolation | ↑ | |
Baglietto-Vargas et al. (2015) [89] | 3xTg AD | 5 h of multimodal stress. Brief restraint, shaker plate with bright lights and noise | ↑ | |
Park et al. (2015) [44] | C57BL/6 J | 3 h restraint | ↑ | |
Justice et al. (2015) [90] | APP/PS1 | PTSD-like induction for two hours followed by a trigger | ↑ |