Table 4 Studies involving stress paradigms and tau phosphorylation/aggregation
From: Targeting psychologic stress signaling pathways in Alzheimer’s disease
Studies on Tau | Model | Stress paradigm | Effect | Comments |
|---|---|---|---|---|
Rissman et al. (2007) [55] | C57BL/6 J, multiple CRHR knockouts | Acute restraint at multiple time points up to two hours. Also done in adrenalectomized mice. | ↑ | |
Carroll et al. (2011) [54] | PS19 [91] | Variable stressor once per day for 4 weeks, or restraint six hours/day and isolation for one month | ↑ | Variable stress paradigm not consistent in elevating tau measures |
Rissman et al. (2012) [59] | CRHR Knockouts | Half hour restraint one time or daily for 14 days | ↑ | |
Filipcik et al. (2012) [57] | C57BL/6 J | 30 min or 120 min restraint | ↑ | |
Campbell et al. (2015) [51] | CRH overexpressing | ↑ | ||
Le et al. (2016) [58] | Primary Neuronal Culture from C57BL/6 J | Treatment with CRH | ↑ |