Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

Patrick, Ellis; Rajagopal, Sathyapriya; Wong, Hon-Kit Andus; McCabe, Cristin; Xu, Jishu; Tang, Anna; Imboywa, Selina H.; Schneider, Julie A.; Pochet, Nathalie; Krichevsky, Anna M.; Chibnik, Lori B.; Bennett, David A.; De Jager, Philip L.

doi:10.1186/s13024-017-0191-y

Molecular Neurodegeneration

Table 2 P-values from tests of association with AD and other covariates for miRNA implicated in other studies

From: Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

	ROSMAP	Lau	Cogswell	Hebert	Nunez	Study	Age	Sex	NNLS	PMI	RIN	AD	AD (no covariates)
miR-132	Down	Down	Down			0.54	0.58	0.32	0.46	0.0052	7.00E-14	2.00E-08	4.00E-12
miR-129-5p	Down	Down				0.31	0.012	0.72	0.23	6.00E-04	1.70E-11	3.90E-06	6.50E-07
miR-129-3p		Down				0.59	0.089	0.063	0.73	0.0057	3.00E-08	0.0013	0.00098
miR-136		Down				0.59	0.3	0.71	0.16	0.046	0.1	0.67	0.78
miR-370		Down				0.29	0.084	0.025	0.051	0.17	0.0036	0.67	0.57
miR-409-5p		Down				0.52	0.0064	0.22	0.26	0.52	0.071	0.33	0.53
miR-487a		Down				0.89	0.1	0.78	0.79	0.53	5.90E-09	0.8	0.99
miR-92a		Up	Up			0.36	0.81	0.039	0.00056	0.43	7.50E-10	0.95	0.1
miR-27a		Up	Up			0.39	0.69	0.46	0.47	0.53	0.56	0.56	0.6
miR-92b		Up	Up			0.14	0.44	2.70E-05	0.96	0.74	2.30E-18	0.056	0.74
miR-200a		Up				0.95	0.013	0.58	0.65	0.095	2.00E-53	0.018	0.00013
miR-9			Down	Down		0.47	0.15	0.21	0.005	0.65	1.20E-06	0.73	0.39
miR-146b-5p			Down			0.45	0.12	0.92	0.5	0.36	0.0064	0.93	0.84
miR-425			Down			0.35	0.19	0.88	0.34	0.41	0.35	0.29	0.11
miR-30e			Up		Down	0.91	0.043	0.14	0.71	0.33	0.019	0.0048	0.0043
miR-423-5p			Up			0.5	0.023	0.78	0.42	0.076	1.80E-07	0.38	0.25
miR-27b			Up			0.19	0.57	0.84	0.66	0.16	0.08	0.48	0.38
miR-100			Up			0.13	0.99	0.0091	0.11	0.16	8.70E-05	0.011	0.0083
miR-34a			Up			0.4	0.00015	0.056	0.013	0.39	0.59	0.18	0.028
miR-145			Up			0.015	0.63	0.96	0.89	0.55	5.50E-06	0.26	0.084
miR-381			Up			0.55	0.73	0.12	0.74	0.6	0.47	0.12	0.022
miR-125b			Up			0.28	0.42	0.92	0.66	0.6	3.20E-10	0.63	0.37
miR-148a			Up			0.19	0.74	0.22	0.23	0.97	0.016	0.95	0.69
miR-15a				Down	Down	0.47	0.24	0.49	0.016	0.0053	0.031	0.51	0.48
miR-29b				Down	Down	0.98	0.27	0.15	0.99	0.057	0.00017	0.34	0.019
miR-101				Down	Down	0.77	0.24	0.013	0.21	0.099	0.96	0.3	0.15
miR-181c				Down	Down	0.13	0.49	0.24	0.038	0.23	0.42	0.34	0.3
miR-363				Down		0.2	0.027	0.13	0.2	0.072	0.096	0.92	0.54
miR-19b				Down		0.72	0.05	0.069	0.34	0.18	0.65	0.064	0.032
miR-106b				Down		0.25	0.92	0.95	0.68	0.3	0.82	0.15	0.13
miR-22				Down		0.84	0.35	0.75	0.16	0.64	0.15	0.81	0.77
miR-93				Down		0.11	0.7	0.0064	0.81	0.74	0.03	0.34	0.2
miR-26b				Down		0.34	0.36	0.25	0.94	0.76	0.67	0.13	0.21
let-7i				Down		0.46	0.79	0.79	0.58	0.93	0.39	0.045	0.036
miR-320a				Up	Up	0.44	0.24	0.26	0.78	0.38	4.60E-14	0.16	0.057
miR-197				Up		0.23	0.43	0.49	0.36	0.31	0.39	0.77	0.43
miR-29c					Down	0.87	0.36	0.43	0.089	0.0082	2.00E-06	0.35	0.31
miR-494					Down	0.61	0.4	0.94	0.5	0.044	2.50E-11	0.38	0.16
miR-598					Down	0.26	1	0.25	9.70E-05	0.1	0.0034	0.2	0.11
miR-374a					Down	0.84	0.48	0.74	0.081	0.35	0.039	0.63	0.72
miR-376a					Down	0.93	0.58	0.027	0.16	0.58	0.71	0.11	0.012
miR-148b					Down	0.89	0.15	0.69	0.12	0.6	0.92	0.72	0.75
miR-95					Down	0.51	0.76	0.33	0.0017	0.71	0.056	0.86	0.74
miR-582-5p					Down	0.6	0.86	0.94	0.012	0.89	0.00018	0.35	0.18
miR-432					Up	0.59	0.32	0.99	0.16	0.084	0.53	0.12	0.1
miR-188-5p					Up	0.8	0.82	0.18	0.4	0.12	0.011	0.99	0.76
miR-382					Up	0.83	0.51	0.29	0.15	0.52	0.029	0.33	0.28
miR-185					Up	0.92	0.19	0.77	0.055	0.81	0.41	0.013	0.0044

In bold are the tests which meet the Bonferroni correction threshold of p < 0.00016

Back to article page

ISSN: 1750-1326

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com