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Table 3 Integrated analysis of miRNA and their target mRNA identifies miR:target combinations that are associated with AD

From: Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

miRNA Pathways Direction Score Genes in pathway targeted by miRNA
miR-132 protein deacetylation; protein deacylation; macromolecule deacylation Down 1.17E-09 EP300, NACC2, SALL1, SREBF1, SIRT1
miR-200a anion transport Up 1.07E-07 SLC20A1, SLC25A3, RIMS1, SLC35A1, SLC35D1, GLS, ATP8A2, ATP8A1, IRS2, SLC38A9, CXCL12, SLC16A7, SLC18A2
miR-129-5p regulation of transcription, DNA-templated Down 1.19E-07 EP300, NCOA1, ZBTB20, PBX3, LMNA, ZBTB5, ETS1, CHD7, CBX4, WWC2, YWHAB, CBX7, PKNOX1, ZBTB10, CBX6, PHIP, ZFY
miR-129-5p cell migration; cell motility; localization of cell Down 1.19E-07 SUN2, DLC1, LMNA, TMEM201, ETS1, RPS6KB1
miR-129-5p positive regulation of transcription, DNA-templated; positive regulation of transcription from RNA polymerase II promoter; positive regulation of RNA metabolic process; positive regulation of RNA biosynthetic process; positive regulation of nucleic acid-templated transcription Down 1.19E-07 EP300, NCOA1, LMNA, ETS1, PKNOX1, PHIP
miR-129-5p regulation of RNA metabolic process; regulation of nucleic acid-templated transcription; regulation of RNA biosynthetic process Down 1.19E-07 EP300, NCOA1, ZBTB20, PBX3, LMNA, ZBTB5, ETS1, CHD7, CBX4, WWC2, YWHAB, ACTN1, CBX7, PKNOX1, ZBTB10, CBX6, PHIP, ZFY
miR-129-5p cardiovascular system development; circulatory system development Down 1.19E-07 EP300, DLC1, LMNA, ETS1, CHD7, PKNOX1, TIPARP
miR-129-5p single-organism organelle organization Down 1.19E-07 SUN2, EP300, DLC1, NCOA1, LMNA, VAMP1, WHAB, SNX9, ACTN1, PAPD5, PHIP