Table 3 Integrated analysis of miRNA and their target mRNA identifies miR:target combinations that are associated with AD
miRNA | Pathways | Direction | Score | Genes in pathway targeted by miRNA |
|---|---|---|---|---|
miR-132 | protein deacetylation; protein deacylation; macromolecule deacylation | Down | 1.17E-09 | EP300, NACC2, SALL1, SREBF1, SIRT1 |
miR-200a | anion transport | Up | 1.07E-07 | SLC20A1, SLC25A3, RIMS1, SLC35A1, SLC35D1, GLS, ATP8A2, ATP8A1, IRS2, SLC38A9, CXCL12, SLC16A7, SLC18A2 |
miR-129-5p | regulation of transcription, DNA-templated | Down | 1.19E-07 | EP300, NCOA1, ZBTB20, PBX3, LMNA, ZBTB5, ETS1, CHD7, CBX4, WWC2, YWHAB, CBX7, PKNOX1, ZBTB10, CBX6, PHIP, ZFY |
miR-129-5p | cell migration; cell motility; localization of cell | Down | 1.19E-07 | SUN2, DLC1, LMNA, TMEM201, ETS1, RPS6KB1 |
miR-129-5p | positive regulation of transcription, DNA-templated; positive regulation of transcription from RNA polymerase II promoter; positive regulation of RNA metabolic process; positive regulation of RNA biosynthetic process; positive regulation of nucleic acid-templated transcription | Down | 1.19E-07 | EP300, NCOA1, LMNA, ETS1, PKNOX1, PHIP |
miR-129-5p | regulation of RNA metabolic process; regulation of nucleic acid-templated transcription; regulation of RNA biosynthetic process | Down | 1.19E-07 | EP300, NCOA1, ZBTB20, PBX3, LMNA, ZBTB5, ETS1, CHD7, CBX4, WWC2, YWHAB, ACTN1, CBX7, PKNOX1, ZBTB10, CBX6, PHIP, ZFY |
miR-129-5p | cardiovascular system development; circulatory system development | Down | 1.19E-07 | EP300, DLC1, LMNA, ETS1, CHD7, PKNOX1, TIPARP |
miR-129-5p | single-organism organelle organization | Down | 1.19E-07 | SUN2, EP300, DLC1, NCOA1, LMNA, VAMP1, WHAB, SNX9, ACTN1, PAPD5, PHIP |