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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

Fig. 6

Young APP/PS1–21 mice display an early global and compartmentalized astrocytic hyperactivity. a Within the global astrocytic population, proportion of astrocytes displaying calcium activity and frequency of calcium activity in APP/PS1–21 mice (orange; n = 8) and their littermates (WT, grey; n = 8) in physiological condition or with 40 μM HC 030031 (cyan, n = 7). b Frequency histogram showing the occurrence of Ca2+ events in the astrocyte population of APP/PS1–21 (orange), WT (grey) and APP/PS1–21 mice treated with 40 μM HC 030031 (cyan). Related theoretical Poisson distributions were shown accordingly. Pie chart representing inactive, active and hyperactive astrocytes in WT and APP/PS1–21 mice treated or not with HC 030031. c Within single astrocyte arbor, proportion of subregions displaying calcium activity and frequency of calcium activity in APP/PS1–21 mice (orange; n = 4) and their littermates (WT, grey; n = 4) in physiological condition or with 40 μM HC 030031 (cyan, n = 7). Results are compared with the WT mice with *, p < 0.05; **, p < 0.01 and ***, p < 0.001 or the APP/PS1–21 mice with #, p < 0.05; ##, p < 0.01 and ###, p < 0.001

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