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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

Fig. 4

Absolute levels of soluble α-syn in the brains of PLP- α-syn mice remain unchanged after systemic chronic TLR4 agonist treatment. a TX soluble and b SDS soluble levels of α-syn were unaffected by the LPS or MPLA treatments. c The increase in the concentration of α-syn in the SDS fraction positively correlated with the increase in the RD of SDS-soluble monomeric species. In contrast, the higher concentration of α-syn measured in the SDS fraction by ELISA correlated with the lower RD of insoluble oligomeric α-syn species in the urea fraction, suggesting that the tendency of increased levels of α-syn after MPLA 50 in the SDS fraction may reflect the reduction of toxic insoluble oligomeric species after this treatment in PLP-α-syn mice. Data are means ± SEM, n = 4 per group

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