Fig. 6
Systemic MPLA treatment of PLP-α-syn mice reduces the density of GCIs. a Three different antibodies to α-syn (15G7, 5G4, and pS129) were used to identify GCI-like accumulation of α-syn (arrows) in the brains of PLP-α-syn. b Image analysis demonstrated significant reduction of the density of GCIs in the SNc of PLP-α-syn mice treated with MPLA 100 μg as compared to vehicle-treated animals (Data are means ± SEM, nvehicle = 13, nLPS = 3, nMPLA50 = 13, nMPLA100 = 12.* p < 0.05, ** p < 0.01). c The decrease in the nigral GCI density significantly correlated with the motor improvement of the PLP-α-syn mice as measured by Ttotal of the pole test