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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: TREM2 in Neurodegenerative Diseases

Fig. 2

TREM2 can be present as a full-length protein (shown at top) or as a soluble product. This can occur through proteolytic cleavage by ADAM10 followed by γ-secretase to produce soluble TREM2 (sTREM2), a C-terminal fragment (CTF) and an intracellular domain (ICD). TREM2 can also be alternatively spliced to produce soluble isoforms. One alternative transcript has been validated in mice, while two have been validated in humans and four others are predicted to occur [51, 132, 133, 161, 225, 228, 230, 232]

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