Fig. 6
From: Absence of CX3CR1 impairs the internalization of Tau by microglia
The impaired phagocytic capacity of microglia increases in advanced stages of AD. a Representative immunofluorescence images of phagocytic pouche (yellow arrow) in a microglial cell (Iba1, green) of human AD tissue. b Quantification of the number of phagocytic pouches per microglial cell. c Quantification of nucleus area of microglia in human tissue. d Quantification of CX3CL1 fluorescence intensity present in the human hippocampus in AD. Bars show means ± S.E. + p ≤ 0.05; ∗p ≤ 0.05; ∗∗ p ≤ 0.01 and ∗∗∗p ≤ 0.001. Purple scale bar: 40 μm. N, microglia nucleus (DAPI)