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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa

Fig. 6

Effect of S1R knockout on rod electrophysiological responses in rd10 mice. Rod ERG recording was performed with scotopic flash stimulation at indicated flash intensities and time points, as described in Methods. a. Average plot of a-wave amplitudes of rd10/S1R+/+ mice and rd10/S1R-/- mice. The dashed green line serves as a reference for comparison between two plots. b. Comparison of a-wave amplitude averages (30 cd.s/m2) in the presence and absence of S1R. c. Separately plotted average b-wave amplitudes of rd10/S1R+/+ and rd10/S1R-/- mice. d. Comparison of b-wave amplitude averages (30 cd.s/m2) in the presence and absence of S1R. ERG a-wave is the downward deflected negative response; b-wave is from the a-wave peak to positive response peak. Quantification: Mean ± SE, n = 5–7 mice; *P < 0.05

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