Fig. 6
From: Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A
Blocking ESCRT dependent ILV formation increases tau phosphorylation at serine 369 (S396). a Western blot of transfected N2a Swe cells demonstrates increased tau phosphorylation at S396 with expression of dnVPS4A. b Quantification of A shows a 56% increase in levels tau phosphorylated at S396 with dnVPS4A; values are normalized against actin and expressed as percentage of ctrGFP, (n = 5, *p < 0.05)