TY - JOUR AU - Zhou, Xiaolai AU - Paushter, Daniel H. AU - Feng, Tuancheng AU - Sun, Lirong AU - Reinheckel, Thomas AU - Hu, Fenghua PY - 2017 DA - 2017/08/23 TI - Lysosomal processing of progranulin JO - Molecular Neurodegeneration SP - 62 VL - 12 IS - 1 AB - Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for proper lysosome function. However, the metabolism of PGRN in the lysosome is still unclear. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-017-0205-9 DO - 10.1186/s13024-017-0205-9 ID - Zhou2017 ER -