Fig. 1
From: The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
Post-translational modifications of HSF1 in relation to the functional domains in the protein. The HSF1 protein consists of a DNA-binding domain (DBD), four leucine zipper domains (LZD), a regulatory domain (RD) and a transactivating domain (TAD). The proposed sites of serine/threonine phosphorylation (P), lysine acetylation (A) and phosphorylation-dependent lysine SUMOylation (S) are marked on the HSF1 amino acid chain. These post-translational modifications are mediated by numerous kinases, acetylases and SUMOylases and act to modulate the stabilization and activity of HSF1 and thus the strength and duration of the HSR