The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

Table 1 List of Hsps and whether their expression is up-regulated (↑), down-regulated (↓), or not changed (No ∆) across rodent models of HD compared to transgenic WT or non-transgenic mouse controls

Hsps	Transgenic disease models	Tissue or cell type	Reference
HSF1	STHdh(Q111) knock-in mice	IB: 80% ↓striatal and cerebellar tissue homogenates	[32, 74]
αB-c (HSPB5)	R6/2	IB: No Δ whole brain homogenates	[72]
αB-c (HSPB5)	Htt-N171-82Q	IB: No Δ spinal cord homogenates	[79]
Hsp25 (HSPB1)	R6/2	IB: No Δ whole brain homogenates	[72]
Hsp25 (HSPB1)	Htt-N171-82Q	IB: No Δ spinal cord homogenates	[79]
Hsp40	R6/2	IB: 60% ↓Hdj1 whole brain homogenates IB: 25% ↓Hdj2 whole brain homogenates	[72]
Hsp60	R6/2	LC-MS: 4-fold ↓ in protein abundance in the cortex LC-MS: 4-fold ↑ in protein abundance in the striatum	[80]
Hsp70	STHdh(Q111) knock-in mice	IB: 80% ↓striatal and cerebellar tissue homogenates	[32]
Hsp70	R6/2	IB: ↓ whole brain homogenates IB: No Δ Hsc70 whole brain homogenates	[72]
Hsp90	R6/2	IB: No Δ Hsp90 whole brain homogenates IB: No Δ Hsp84 whole brain homogenates	[72]
Hsp105	–	–	–

These results are from immunoblot (IB), or liquid chromatography coupled with quantitative mass spectrometry (LC-MS) of affected CNS regions

ISSN: 1750-1326