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Table 1 List of Hsps and whether their expression is up-regulated (↑), down-regulated (↓), or not changed (No ∆) across rodent models of HD compared to transgenic WT or non-transgenic mouse controls

From: The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

Hsps Transgenic disease models Tissue or cell type Reference
HSF1 STHdh(Q111) knock-in mice IB: 80% ↓striatal and cerebellar tissue homogenates [32, 74]
αB-c (HSPB5) R6/2 IB: No Δ whole brain homogenates [72]
Htt-N171-82Q IB: No Δ spinal cord homogenates [79]
Hsp25 (HSPB1) R6/2 IB: No Δ whole brain homogenates [72]
Htt-N171-82Q IB: No Δ spinal cord homogenates [79]
Hsp40 R6/2 IB: 60% ↓Hdj1 whole brain homogenates
IB: 25% ↓Hdj2 whole brain homogenates
[72]
Hsp60 R6/2 LC-MS: 4-fold ↓ in protein abundance in the cortex
LC-MS: 4-fold ↑ in protein abundance in the striatum
[80]
Hsp70 STHdh(Q111) knock-in mice IB: 80% ↓striatal and cerebellar tissue homogenates [32]
R6/2 IB: ↓ whole brain homogenates
IB: No Δ Hsc70 whole brain homogenates
[72]
Hsp90 R6/2 IB: No Δ Hsp90 whole brain homogenates
IB: No Δ Hsp84 whole brain homogenates
[72]
Hsp105
  1. These results are from immunoblot (IB), or liquid chromatography coupled with quantitative mass spectrometry (LC-MS) of affected CNS regions