Skip to main content

Table 2 Most significant genes associated with WMH (FDR < 0.05)

From: Whole blood gene expression and white matter Hyperintensities

Gene

Primary analysisa

Secondary analysisa

Effect size

SEb

P-value

FDRc

Direction of effectd

Effect size

SEb

P-value

Direction of effectd

IL4R

−0.055

0.010

1.5E-08

2.6E-04

↓

−0.050

0.010

3.6E-07

↓

CD79A

−0.069

0.013

2.7E-07

2.5E-03

↓

−0.067

0.014

1.0E-06

↓

FCRL6

0.068

0.013

5.2E-07

3.1E-03

↑

0.064

0.014

2.8E-06

↑

PAX5

−0.052

0.011

3.1E-06

1.4E-02

↓

−0.049

0.011

1.6E-05

↓

FCRL1

−0.066

0.014

4.8E-06

1.7E-02

↓

−0.059

0.015

5.8E-05

↓

BANK1

−0.060

0.014

8.6E-06

2.1E-02

↓

−0.057

0.014

3.4E-05

↓

ARHGAP10

0.029

0.007

9.4E-06

2.1E-02

↑

0.028

0.007

1.9E-05

↑

YY1

0.018

0.004

9.5E-06

2.1E-02

↑

0.019

0.004

3.5E-06

↑

TGFBR3

0.047

0.011

1.8E-05

3.6E-02

↑

0.044

0.011

6.4E-05

↑

IL1RL2

0.021

0.005

2.2E-05

3.7E-02

↑

0.020

0.005

6.1E-05

↑

SEPT11

0.033

0.008

2.3E-05

3.7E-02

↑

0.034

0.008

1.2E-05

↑

TREML2

−0.029

0.007

2.6E-05

3.9E-02

↓

−0.026

0.007

2.2E-04

↓

ARL17A

−0.100

0.024

3.2E-05

4.4E-02

↓

−0.097

0.025

7.8E-05

↓

  1. aPrimary analysis was adjusted for age, sex, total cranial volume and cohort, whereas secondary analysis was additional adjusted for smoking, body mass index, systolic blood pressure, diastolic blood pressure, hypertension treatment, total cholesterol, HDL cholesterol, and triglycerides
  2. bSE: standard error
  3. cFDR: false discovery rate
  4. dDirection of effect: ↓ indicates decreased gene expression was associated with increased WMH, whereas ↑ indicates increased gene expression was associated with increased WMH