From: Whole blood gene expression and white matter Hyperintensities
GWAS SNP | Risk allelea | Locus | P value (GWAS association with WMH) [46] | Association of SNPs with gene expression by eQTL analysis [44] | Association of eGene expression with WMH (current study) | ||||
---|---|---|---|---|---|---|---|---|---|
eGene | P value | Direction on gene expressionb | Effect sizea | SEc | P value | ||||
rs4072479 | C | 17q25.1 | 4.6E-14 | WBP2 | 1.0E-10 | ↓ | −0.020 | 0.010 | 4.6E-02 |
rs8067275 | T | 17q25.1 | 1.9E-13 | MYO15B | 2.3E-05 | ↑ | 0.003 | 0.005 | 0.52 |
rs9894244 | A | 17q25.1 | 5.2E-10 | GALK1 | 2.9E-06 | ↓ | 0.001 | 0.004 | 0.79 |
rs9894244 | A | 17q25.1 | 5.2E-10 | ITGB4 | 2.9E-06 | ↓ | −0.001 | 0.003 | 0.79 |
rs7216615 | C | 17q25.1 | 1.1E-09 | H3F3B | 9.2E-29 | ↓ | −0.007 | 0.008 | 0.38 |
rs34143128 | C | 17q25.1 | 2.4E-09 | ACOX1 | 9.1E-50 | ↓ | 0.003 | 0.009 | 0.75 |
rs1135889 | A | 17q25.1 | 8.8E-09 | UNC13D | 4.5E-11 | ↓ | −0.010 | 0.004 | 6.1E-03 |
rs1135889 | A | 17q25.1 | 8.8E-09 | EXOC7 | 9.1E-05 | ↓ | −0.009 | 0.006 | 0.86 |
rs1135889 | A | 17q25.1 | 8.8E-09 | ZACN | 9.1E-05 | ↓ | −0.001 | 0.005 | 0.86 |
rs2984613 | C | 1q22 | 2.0E-08 | C1orf85 | 6.5E-23 | ↓ | −0.003 | 0.007 | 0.65 |
rs2984613 | C | 1q22 | 2.0E-08 | TMEM79 | 6.5E-23 | ↓ | 0.005 | 0.007 | 0.65 |
rs2984613 | C | 1q22 | 2.0E-08 | SMG5 | 3.3E-20 | ↓ | 0.002 | 0.005 | 0.72 |
rs2984613 | C | 1q22 | 2.0E-08 | PAQR6 | 1.6E-16 | ↓ | 0.001 | 0.006 | 0.89 |
rs2984613 | C | 1q22 | 2.0E-08 | PMF1 | 7.3E-10 | ↑ | −0.001 | 0.005 | 0.91 |
rs2984613 | C | 1q22 | 2.0E-08 | SEMA4A | 2.4E-08 | ↓ | −0.022 | 0.006 | 3.4E-04 |
rs10883865 | G | 10q24.33 | 4.6E-08 | AS3MT | 7.9E-26 | ↓ | 0.011 | 0.010 | 0.30 |
rs10883865 | G | 10q24.33 | 4.6E-08 | USMG5 | 7.7E-07 | ↑ | 0.015 | 0.011 | 0.19 |