TY - JOUR AU - Hernandez, Michael X. AU - Jiang, Shan AU - Cole, Tracy A. AU - Chu, Shu-Hui AU - Fonseca, Maria I. AU - Fang, Melody J. AU - Hohsfield, Lindsay A. AU - Torres, Maria D. AU - Green, Kim N. AU - Wetsel, Rick A. AU - Mortazavi, Ali AU - Tenner, Andrea J. PY - 2017 DA - 2017/09/18 TI - Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss JO - Molecular Neurodegeneration SP - 66 VL - 12 IS - 1 AB - Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's disease (AD) mouse models. To validate that the effect of the antagonist was specifically via C5aR1 inhibition, mice lacking C5aR1 were generated and compared in behavior and pathology. In addition, since C5aR1 is primarily expressed on cells of the myeloid lineage, and only to a lesser extent on endothelial cells and neurons in brain, gene expression in microglia isolated from adult brain at multiple ages was compared across all genotypes. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-017-0210-z DO - 10.1186/s13024-017-0210-z ID - Hernandez2017 ER -