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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Fig. 7

Loss of neuronal complexity in the Arctic model is rescued in the absence of C5aR1. The average number of branchings for a given distance from the soma (um) of each neuron by Sholl analysis using the NeuroLucida software within the CA1 area of 10 mo (a) and 7 mo (b) mice (5 neurons/ animal, 3 mice per genotype) +/− SEM. * p < .05 for Arctic vs Arctic/C5aR1KO by 2 way ANOVA followed by Tukey’s multiple comparison test. (c) The same data are plotted to compare the 7 and 10 mo branching in wild type (left), Arctic (middle) and Arctic/C5aR1KO (right) mice, *p < .02 by one way ANOVA

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Molecular Neurodegeneration

ISSN: 1750-1326