Fig. 7From: Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive lossLoss of neuronal complexity in the Arctic model is rescued in the absence of C5aR1. The average number of branchings for a given distance from the soma (um) of each neuron by Sholl analysis using the NeuroLucida software within the CA1 area of 10 mo (a) and 7 mo (b) mice (5 neurons/ animal, 3 mice per genotype) +/− SEM. * p < .05 for Arctic vs Arctic/C5aR1KO by 2 way ANOVA followed by Tukey’s multiple comparison test. (c) The same data are plotted to compare the 7 and 10 mo branching in wild type (left), Arctic (middle) and Arctic/C5aR1KO (right) mice, *p < .02 by one way ANOVABack to article page