Fig. 3
Activation of the polyol pathway of glucose metabolism in the DJ-1 knockout mouse brain. a-f Graphs showing levels of 1,5-anhydroglucitol, fructose, DHAP, glucose, glucose-6-phosphate, and fructose-1,6-bisphosphate in WT and DJ-1 knockout mouse brains. Metabolite levels were determined using a high-content metabolomics screen of 240 biochemicals in 4-month-old mouse brains (n = 13 WT (8 M, 5F), n = 12 DJ-1 knockout (6 M, 6F)). The results of a Welch’s t-test with and without correction for multiple tests using the BH method are displayed beneath each graph. * indicates padj < 0.05. g Summary of alterations in glucose metabolites found in the DJ-1 knockout mouse brain. Note that colors indicate significance before correction for multiple testing