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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s disease

Fig. 3

Changes of amyloid-beta burden in brain regions related olfactory function. (a-d) Gad67 haploinsufficiency 5xFAD mice (AD+GG+) also elicit a reduction of Aβ42 burden (red) in olfactory bulb (OB) (a-b) and piriform cortex (PIRC) (c-d). GFP positive cells were shown in green. N = 6 mice of 10–11 months age in each genotype groups (AD-GG-, AD-GG+, AD+GG-, AD+GG+). For a and c, scale bars represent 30 μm. Data are presented as mean ± s.e.m., * < 0.05; ** < 0.01; *** < 0.001; one-way ANOVA with the Tukey’s post-hoc test when comparing multiple groups

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