Fig. 5

Abnormal tonic inhibition is decreased in 5xFAD mice with Gad67 haploinsufficiency. a Schematic image illustrate the interesting cortical area for electrophysiology study. b A typical phase contrast image showing the whole cell recording in the adult brain slice. Scale bar = 10 μm. c Example of the mIPSCs traces in AD-GG-, AD+GG- and AD+GG+ groups. d Summary graph of mean amplitude and frequency of mIPSCs. e Representative trances of tonic GABA currents. f Quantification data showing the abnormal tonic GABA currents in 5xFAD mice are decreased by Gad67 haploinsufficiency. Data are presented as mean ± s.e.m., * p < 0.05; one-way ANOVA with the LSD post-hoc test