Fig. 4
From: Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury
Combined Jun/Ddit3 deficiency is more protective after axonal injury than Dlk deficiency. a Example images of TUJ1 staining in control and experimental eyes 35 days after ONC (scale bar = 50 μm). b TUJ1+ cell counts showed that Dlk deficient and combined Jun/Ddit3 deficient animals had significantly greater RGC survival than WT mice 35 days after ONC (% given compared to control eyes of same genotype, WT: 20.4% survival, Dlk: 64.3% Jun/Ddit3: 88.5%; *, P < 0.001, n = 8 per condition per genotype except n = 7 for Dlk deficient animals; error bars represent SEM). Importantly, the protection provided by Jun/Ddit3 deficiency was significantly greater than the protection provided by Dlk deficiency alone (P < 0.001)