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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Fig. 2

A myelination/oligodendrocyte enriched module in the multi-tissue AD coexpression network is enriched for AD GWAS genes. The left panel shows a heatmap of the enrichments (BH-adjusted -log10 p-values) of multiscale modules with at least 50 members in marker genes from each of the five major brain cell types, i.e. astrocytes, endothelial cells, microglia, neurons, and myelinating oligodendrocytes, derived from a previous study in mice [32]. The bottom panel shows the enrichment (BH-adjusted -log10 p-values) of each corresponding module in the 543 AD risk genes derived from the IGAP AD GWAS study

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Molecular Neurodegeneration

ISSN: 1750-1326