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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Fig. 4

An oligodendrocyte-enriched protein coexpression module is dysregulated in AD. a Heatmap of transformed correlations in non-AD samples (Braak <= 2; lower left) and AD samples (Braak > = 5; upper right) in the OL-enriched module consisting of 150 proteins. The transformation consists of taking the absolute value of Pearson correlation coefficients raised to the power of β, i.e., the soft-thresholding power coefficient of 3 used in coexpression network construction. b, c Expression levels for MBP (b) and BIN1 (c) in samples classified as non-AD (Braak <= 2), mild AD (Braak 3–4), and AD samples (Braak > = 5). Significance assessed using Student’s t-tests (* = p-value <0.05)

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Molecular Neurodegeneration

ISSN: 1750-1326