Fig. 6

Gene signatures from in vitro and in vivo perturbations of key driver genes in the AD myelin/oligodendrocyte network are significantly enriched in the predicted subnetworks regulated by the driver genes. a, b Fold-enrichment (a) and BH-adjusted -log₁₀ enrichment p-values (b) for the overlap between the Myrf in vitro perturbation signature and each n-layer network neighborhood regulated by MYRF in the core oligodendrocyte Bayesian regulatory network (COLBN). c, d Fold-enrichment (c) and -log₁₀ enrichment p-values (d) for the overlap between each in vivo perturbation signature and each n-layer network neighborhood regulated by the corresponding driver gene. The result was based on the in vivo knockout differentially expressed gene signatures experiments for Cnp, Plp1, and Ugt8 from the cerebellum (CBM) and/or the frontal cortex (FC)