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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Fig. 7

Perturbation of oligodendrocyte network key drivers in mice recapitulates key gene expression changes in human AD brain samples. a A heatmap of the -log10 gene ontology (GO) enrichment p-values of core oligodendrocyte Bayesian regulatory network key driver knockout differentially expressed gene (DEG) signatures (left panel) and AD DEG signatures from the hippocampus and prefrontal cortex (right panel). The top 3 GO terms with between 100 and 800 gene symbols most enriched in each of the DEG signatures are shown. The p-values for each tested signature were adjusted using the Benjamini-Hochberg method. b, c, d Venn diagrams showing the intersections of genes encoding proteins associated with the GO terms “mitochondrial protein complex” (b), “ribosome” (c), and genes in the myelin proteome (d) with genes downregulated in various DEG signatures are shown

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