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Table 2 The members of the core oligodendrocyte gene set (COLGS) that are identified as significant (p < 0.05) AD GWAS hits in the IGAP data set

From: Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Gene Chromosome Top SNP Top SNP P-value
BIN1 2 rs35114168 1.05e-25
PICALM 11 rs639012 4.87e-19
NME8 7 rs2060712 6.30e-07
SNX1 15 rs138194169 2.72e-06
CPM 12 rs10878881 1.48e-05
DLG2 11 rs422267 2.09e-05
RASGRP3 2 rs10200743 2.76e-05
GALNT18 11 rs11021857 4.511e-05
DNAH17 17 rs117779187 7.04e-05
LIPC 15 rs17269397 8.32e-05
ZNF652 17 rs12948660 0.000119
MVB12B 9 rs887656 0.000145
CAV2 7 rs75396674 0.000157
CREB5 7 rs42711 0.000158
NFE2L3 7 rs73281529 0.000224
CDR2L 17 rs117639581 0.000299
PIP4K2A 10 rs11013051 0.000390
TLL2 10 rs11594430 0.000542
RRBP1 20 rs6080757 0.000873
KANK4 1 rs114648128 0.00118
SLC9A9 3 rs10804689 0.00141
HIP1 7 rs10259351 0.00165
CKAP2 13 rs58655347 0.00168
TLE4 9 rs62569297 0.00172
NECAB1 8 rs7003020 0.00194
TBC1D2 9 rs73488713 0.00222
LGR5 12 rs75928881 0.00278
PDE4B 1 rs12138629 0.00374
PDE11A 2 rs4893975 0.00380
PAPSS1 4 rs62313402 0.00387
DFNB31 9 rs10817615 0.00450
MBP 18 rs8095585 0.00484
LACTB2 8 rs10097463 0.00545
ALCAM 3 rs114219776 0.00628
TMED7 5 rs10069695 0.00691
CAT 11 rs494024 0.00849
MSI2 17 rs12450585 0.00849
MME 3 rs61758192 0.00885
POC1B 12 rs770369 0.0117
PCDHA1 5 rs2879086 0.0151
ANK3 10 rs117641222 0.0185
FAM214A 15 rs8030871 0.0241
ELMO1 7 rs1420423 0.0333
  1. The p-value column shows the smallest p-value of any associated SNP for each gene