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Table 2 The members of the core oligodendrocyte gene set (COLGS) that are identified as significant (p < 0.05) AD GWAS hits in the IGAP data set

From: Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Gene

Chromosome

Top SNP

Top SNP P-value

BIN1

2

rs35114168

1.05e-25

PICALM

11

rs639012

4.87e-19

NME8

7

rs2060712

6.30e-07

SNX1

15

rs138194169

2.72e-06

CPM

12

rs10878881

1.48e-05

DLG2

11

rs422267

2.09e-05

RASGRP3

2

rs10200743

2.76e-05

GALNT18

11

rs11021857

4.511e-05

DNAH17

17

rs117779187

7.04e-05

LIPC

15

rs17269397

8.32e-05

ZNF652

17

rs12948660

0.000119

MVB12B

9

rs887656

0.000145

CAV2

7

rs75396674

0.000157

CREB5

7

rs42711

0.000158

NFE2L3

7

rs73281529

0.000224

CDR2L

17

rs117639581

0.000299

PIP4K2A

10

rs11013051

0.000390

TLL2

10

rs11594430

0.000542

RRBP1

20

rs6080757

0.000873

KANK4

1

rs114648128

0.00118

SLC9A9

3

rs10804689

0.00141

HIP1

7

rs10259351

0.00165

CKAP2

13

rs58655347

0.00168

TLE4

9

rs62569297

0.00172

NECAB1

8

rs7003020

0.00194

TBC1D2

9

rs73488713

0.00222

LGR5

12

rs75928881

0.00278

PDE4B

1

rs12138629

0.00374

PDE11A

2

rs4893975

0.00380

PAPSS1

4

rs62313402

0.00387

DFNB31

9

rs10817615

0.00450

MBP

18

rs8095585

0.00484

LACTB2

8

rs10097463

0.00545

ALCAM

3

rs114219776

0.00628

TMED7

5

rs10069695

0.00691

CAT

11

rs494024

0.00849

MSI2

17

rs12450585

0.00849

MME

3

rs61758192

0.00885

POC1B

12

rs770369

0.0117

PCDHA1

5

rs2879086

0.0151

ANK3

10

rs117641222

0.0185

FAM214A

15

rs8030871

0.0241

ELMO1

7

rs1420423

0.0333

  1. The p-value column shows the smallest p-value of any associated SNP for each gene