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Table 3 Of the 40 top-ranked key drivers from the core oligodendrocyte-enriched Bayesian network (COLBN), 4 have a type of perturbation signature that we used to validate the network, either in vitro or in vivo

From: Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Gene Symbol Major Annotated Roles of Gene Product Myelin OL Exosome Lipid-Binding AD Risk Perturbation
ERMN Myelination Yes     
UGT8 Galactocerebroside production    Yes   In vivo; this study
CNP Myelination; Axon interaction Yes Yes    In vivo; this study
ENPP2 LPA production      
FRMD4B ?     
PLEKHH1 ?     
SLC44A1 Choline transporter Yes    
TRIM59 ?     
PLLP Myelination Yes   Yes  
PRRG1 ?     
SOX2-OT lncRNA     
CONTIG36931_RC ?     
CLDND1 ?     
ANLN Actin cytoskeleton Yes    
TTYH2 Chloride channel     
MYRF OL differentiation      In vitro; [49]
FA2H Ceramide hydroxylation    Yes   
CARNS1 Carnosine production     
RNLS Alpha-NAD(P)H oxidase     
RASSF2 Apoptosis     
PRR18 ?     
RTKN Rho pathway     
DOCK10 Rho pathway     
LPAR1 LPA receptor Yes   Yes  
MAG Myelination Yes    
TF Iron transport     
TMEM125 ?     
PLP1 Myelination; Axon interaction Yes Yes Yes   In vivo; this study
RHBDL2 Protease activity      
NKX6–2 OL differentiation     
FOLH1 Folate hydrolase Yes    
PSEN1 Protease activity     Yes
MAN2A1 Glycosylation     
PLA2G16 Phospholipase    Yes  
CONTIG56276_RC ?     
ABCA2 Sterol transport     Yes
CREB5 ?     Yes
GPR62 ?     
SLC31A2 Copper transport     
LAMP2 Glycosylation     
  1. The Major Annotated Roles of Gene Product column is based on a literature review for the major known role(s) of that gene’s product in oligodendrocytes, for which a question mark indicates that no major role is known, to the best of our knowledge. The Myelin column indicates whether or not that gene encodes a protein found in in the myelin proteome [43], the OL Exosome column indicates whether or not that gene encodes a protein found in the OL exosome proteome [97], and the lipid-binding column indicates whether or not that gene encodes a protein found in the set of lipid-binding proteins [98]. The AD risk indicates whether a variant associated with the gene has been previously associated with AD risk, and the Perturbation column indicates whether there is a perturbation signature that we used to corroborate the downstream neighborhood topology for that key driver