Fig. 5

Pathway analysis highlights mitochondrial alterations associated with altered synaptic function and a broad range of neurodegenerative diseases, mediated by complex 1. a. 411 differentially expressed mitochondrial proteins are implicated in the literature as contributors to neurological disease, psychological disorders and skeletal and muscular disorders. b. Mitochondrial complex 1 is central to the network of interactions (highlighted in light blue) and features a number of intrinsic mitochondrial proteins and 2 protein families. Expression of the synaptic mitochondrial proteome is associated with perturbed synaptic structure and function. c. The significant differential expression of proteins in synaptic and non-synaptic compartments appears to inhibit downstream pathways associated with synaptic transmission. Solid lines indicate direct interactions; dashed lines represent indirect interactions; proteins highlighted in pink are those which are more abundant in synaptic mitochondria; proteins in green are those which are more abundant in non-synaptic mitochondria; dark blue represents predicted pathway inhibition. Shapes are indicative of protein function: diamond = enzyme; rectangle = GPCR; square = cytokine; trapezoid = transporter; circle = other