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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture

Fig. 7

Manipulation of the mitochondrial proteome modulates active zone expression. a. Representative images of WT, NDUFB8 and ALDH muscle 12 NMJs from abdominal segment A3 (n = 8) immunostained with anti-HRP and anti-bruchpilot. Bottom panel displays ImageJ quantification mask utilized for HRP staining. b. Quantification of total bouton area in NDUFB8 and ALDH RNAi lines (as displayed in Fig. 6i). c. Quantification of total NMJ active zone area in NDUFB8 and ALDH RNAi lines (Control mean ± SEM = 0.87 ± 0.04; Ndufb8 p<0.0001, mean ± SEM = 0.62 ± 0.03; Aldh p<0.0001, mean ± SEM = 0.64 ± 0.04. All quantification used students t-test (n = 8); * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001. Scale bar = 10um

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