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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Fig. 4

hnRNP Q and hnRNP F regulate the haplotype-specific inclusion of MAPT exon 3 (a) Mean fold change in the normalised H1:H2 MAPT exon 3 transcript ratios in SK-N-F1 cells transfected with siRNA against different splice factors (n = 3–6), a negative siRNA control and a mock transfection (n = 8). hnRNP F (1.47 ± 0.19, p < 0.0001), hnRNP Q (1.28 ± 0.26, p < 0.05). Statistical significance was determined by comparing each column to the mock control (0.96 ± 0.08) using one way ANOVA with Bonferroni correction. Error bars represent standard deviation. b Mean fold change in the normalised H1:H2 total MAPT transcript ratios in SK-N-F1 cells transfected with siRNA against different splice factors

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Molecular Neurodegeneration

ISSN: 1750-1326