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Table 1 Identifying candidate splice factors interacting with H1 and H2 rs17651213 alleles

From: Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Gene Symbol

Description

Ratio H1:H2

±S.D.

SFPQ

Splicing Factor Proline And Glutamine Rich

2.4

0.5

TARDBP

TAR DNA Binding Protein

2.2

0.1

HNRNPM

Heterogeneous Nuclear Ribonucleoprotein M

2.0

0.3

ELAVL1

ELAV Like RNA Binding Protein 1

2.0

0.1

HNRNPH3

Heterogeneous Nuclear Ribonucleoprotein H3

1.9

0.3

HNRNPA0

Heterogeneous Nuclear Ribonucleoprotein A0

1.7

0.2

PTBP1

Polypyrimidine Tract Binding Protein 1

1.7

0.0

hnRNPQ

Heterogeneous Nuclear Ribonucleoprotein Q

1.6

0.5

HNRNPA2B1

Heterogeneous Nuclear Ribonucleoprotein A2/B1

1.6

0.3

PTBP2

Polypyrimidine Tract Binding Protein 2

1.3

0.2

KHDRBS3

KH RNA Binding Domain Containing, Signal Transduction Associated 3

1.3

0.1

HNRNPFa

Heterogeneous Nuclear Ribonucleoprotein F

1.2

0.1

  1. H1 and H2 rs17651213 RNA-pull down of SK-N-F1 nuclear proteins followed by mass spectrometry identification. The values of the mean abundance ratio of proteins interacting with H1: H2 probes were reported with the standard deviation (S.D.). aProteins predicted to bind the H1 and/or H2 probe sequences by SFmap, ESE and SpliceAid2. Splice factors exhibit preferential bindings of 20% or above to either H1 or H2 alleles