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Table 2 Identifying candidate splice factors interacting with H1 and H2 rs1800547 alleles

From: Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Gene Symbol

Description

Ratio H1:H2

±S.D.

KHDRBS3

KH RNA Binding Domain Containing, Signal Transduction Associated 3

3.1

0.6

ELAVL1

ELAV Like RNA Binding Protein 1

2.6

1.4

PCBP1

Poly(RC) Binding Protein 1

2.2

0.1

RBMX

RNA Binding Motif Protein, X-Linked

2.1

0.7

HNRNPK

Heterogeneous Nuclear Ribonucleoprotein K

1.5

0.2

HNRNPU

Heterogeneous Nuclear Ribonucleoprotein U

1.5

0.2

HNRNPA2B1a

Heterogeneous Nuclear Ribonucleoprotein A2/B1

1.5

0.4

PCBP2

Poly(RC) Binding Protein 2

1.4

0.2

KHDRBS1

KH RNA Binding Domain Containing, Signal Transduction Associated 1

0.8

0.1

SFPQ

Splicing Factor Proline And Glutamine Rich

0.8

0.3

HNRNPM

Heterogeneous Nuclear Ribonucleoprotein M

0.8

0.2

SRSF3

Serine And Arginine Rich Splicing Factor 3

0.8

0.3

SF3B1

Splicing Factor 3b Subunit 1

0.7

0.3

hnRNPQ

Heterogeneous Nuclear Ribonucleoprotein Q

0.3

0.2

PTBP1

Polypyrimidine Tract Binding Protein 1

0.2

0.2

  1. H1 and H2 rs17651213 RNA-pull down of SK-N-F1 nuclear proteins followed by mass spectrometry identification. The values of the mean abundance ratio of proteins interacting with H1: H2 probes were reported with the standard deviation (S.D.). aProteins predicted to bind the H1 and/or H2 probe sequences by SFmap, ESE and SpliceAid2. Splice factors exhibit preferential bindings of 20% or above to either H1 or H2 alleles