Table 1 Human NADPH oxidases genes, genomic positions and isoforms
From: NADPH oxidases in Parkinson’s disease: a systematic review
NADPH oxidase catalytic subunit | Official Gene symbol and Full Name HUGOa | Other Proposed Aliasesb | Entrez Gene IDdb | Genomic locationb | mRNA (RefSeq Accession Numbers; GRCh38/hg38 human genome)c | |
|---|---|---|---|---|---|---|
Nox1 | NOX1 | NADPH oxidase 1 | MOX1; NOH1; NOH-1; GP91-2 | 27035 | Xq22.1 | NM_007052 (isoform 1) |
NM_013955 (isoform 2) | ||||||
NM_001271815 (isoform 3) | ||||||
Nox2 | CYBB | cytochrome b-245 beta chain | CGD; NOX2; IMD34; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX | 1536 | Xp21.1-p11.4 | NM_000397 → NP_000388 |
Nox3 | NOX3 | NADPH oxidase 3 | het; GP91-3; nmf250 | 50508 | 6q25.3 | NM_015718 → NP_056533 |
Nox4 | NOX4 | NADPH oxidase 4 | KOX; KOX-1; RENOX | 50507 | 11q14.3 | NM_016931 (isoform a) |
NM_001143836 (isoform b) | ||||||
NM_001143837 (isoform c) | ||||||
NM_001291926 (isoform d) | ||||||
NM_001291927 (isoform e) | ||||||
NM_001291929 (isoform f) | ||||||
NM_001300995 (isoform g) | ||||||
NR_120406 | ||||||
Nox5 | NOX5 | NADPH oxidase 5 | NOX5A, NOX5B | 79400 | 15q23 | NM_024505 (isoform 1) |
NM_001184779 (isoform 2) | ||||||
NM_001184780 (isoform 3) | ||||||
NR_033671 | ||||||
NR_033672 | ||||||
Duox1 | DUOX1 | dual oxidase 1 | LNOX1; THOX1; NOXEF1 | 53905 | 15q21.1 | NM_017434 (dual oxidase 1 precursor) |
NM_175940 (dual oxidase 1 precursor) | ||||||
Duox2 | DUOX2 | dual oxidase 2 | TDH6; LNOX2; THOX2; NOXEF2; P138-TOX | 50506 | 15q21.1 | NM_001190392 dual oxidase 2 precursor |
NM_177610 dual oxidase 2 precursor | ||||||
NM_213999 dual oxidase 2 precursor | ||||||
NM_024141 dual oxidase 2 precursor | ||||||