TY - JOUR AU - Ciervo, Yuri AU - Ning, Ke AU - Jun, Xu AU - Shaw, Pamela J. AU - Mead, Richard J. PY - 2017 DA - 2017/11/13 TI - Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis JO - Molecular Neurodegeneration SP - 85 VL - 12 IS - 1 AB - Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition where loss of motor neurons within the brain and spinal cord leads to muscle atrophy, weakness, paralysis and ultimately death within 3–5 years from onset of symptoms. The specific molecular mechanisms underlying the disease pathology are not fully understood and neuroprotective treatment options are minimally effective. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-017-0227-3 DO - 10.1186/s13024-017-0227-3 ID - Ciervo2017 ER -