Fig. 4
From: Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis
Delivery strategies for the transplantation of MSCs in ALS. a Intrathecal delivery of MSCs into the spinal cord CSF; b Systemic delivery of MSCs; c Local delivery of MSCs directly into the spinal cord parenchyma. For each delivery route, advantages and disadvantages are summarized