Fig. 5

Dendritic calcium transients with abnormal long-durations reduce peak amplitudes of spine calcium transients in APP/PS1 mice. a. Distributions of individual dendritic calcium transients in WT and APP/PS1 mice during running (WT: 4 mice, 297 calcium transients; APP/PS1:5 mice, 543 calcium transients. Mann-Whitney U Test). b. Schematic showing a dendritic branch exhibiting three dendritic calcium transients (1st, 2nd and 3rd) during a running trial. The peak ΔF/F₀ of spine calcium transients was compared between 1st and 3rd image to examine the potential effect of the 2nd dendritic calcium activity. c-d. Changes of spine peak ΔF/F₀ after the 2nd dendritic calcium transient in WT mice.The groups are divided according to the duration of the 2nd dendritic calcium transient: 0–8 s (c) and >8 s (d) respectively (0–8 s, 79 spine calcium transients; > 8 s, 8 spine calcium transients). e-f. Changes of spine peak ΔF/F₀ after the 2nd dendritic calcium transient in APP/PS1 mice.The groups are divided by the duration of the 2nd dendritic calcium transients: 0–8 s (c) and > 8 s (d) respectively (0–8 s, 139 spine calcium transients; > 8 s, 31 spine calcium transients). Data are mean ± s.e.m. *P < 0.05, **P < 0.01. n.s., not significant