Skip to main content

Table 2 Lines with physiological expression of APP, PS1, and Tau

From: Practical considerations for choosing a mouse model of Alzheimer’s disease

Model

Allele

Targeting approach

Availability

Reference

APPNLh

endogenous mouse App with Swe mutation and humanized Aβ domain

Knock-in

NA

[89]

APP R1.40

complete human genomic APP (Swe)

YAC transgenic

MMRRC 34831-JAX

[86]

APPSL

mouse/human App hybrid with humanized Aβ domain (Swe/Lon)

Knock-in

NA

[92]

APPDSL

endogenous mouse App with humanized Aβ domain (Swe/Dutch/Lon)

Knock-in

Hui Zheng

[57]

APPNL, APPNLF, and APPNLGF

endogenous mouse App with humanized Aβ domain and (Swe (NL), Swe/Ibe (NLF), or Swe/Arc/Ibe (NLGF))

Knock-in

Takaomi Saido

[58]

PS1M146V

endogenous mouse Psen1 (M146 V)

Knock-in

JAX 004193

[214]

PS1 KI

endogenous mouse Psen1 (P264L)

Knock-in

NA

[215]

htau

complete human genomic MAPT (wt) with targeted disruption of murine Mapt

PAC transgenic x Mapt KO

JAX 005491

[37]

  1. Tables 1-4: Refer to Fig. 1 for illustration of APP mutations