Table 3 Viral transgenic lines for APP and Tau
From: Practical considerations for choosing a mouse model of Alzheimer’s disease
Transgene | Promoter | Viral packaging | Host | Reference |
|---|---|---|---|---|
Stereotaxically Targeted APP/Aβ Viral Transgenics | ||||
BRI-Aβ40 BRI-Aβ42 | CBA | AAV1 | adult rat | [137] |
huAPP695 (Swe/Lon/Aus) | (human?) EF1A | AAV (serotype not stated) | adult mouse | [138] |
Stereotaxically Targeted Tau Viral Transgenics | ||||
huMAPT 4R2N (P301L) | CAG | AAV2 | adult rat | [142] |
huMAPT 4R0N (P301S) | mouse Pgk | lentivirus | adult mouse | [141] |
huMAPT 4R1N (P301L) | CMV | AAV2 | adult mouse | [216] |
huMAPT 4R2N (P301L) huMAPT 4R2N (wt) | human SYN1 | AAV1 | adult mouse | [217] |
huMAPT 4R1N (P301L) huMAPT 4R1N (wt) | CMV | lentivirus | adult rat | [140] |
huMAPT 4R2N (P301L) | human SYN1 | AAV9 | adult mouse | [218] |
huMAPT 4R0N (P301S) huMAPT 4R0N (wt) | mouse Pgk1 | AAV6 | adult mouse | [219] |
Whole-Brain Tau Viral Transgenics | ||||
huMAPT (P301L) (isoform not stated) | CAG | AAV1 | neonatal mouse | [143] |
huMAPT 4R2N (P301L) | CAG | AAV1 | neonatal mouse | [220] |