Table 4 Controllable transgenic lines for APP and Tau
From: Practical considerations for choosing a mouse model of Alzheimer’s disease
Model | Transgene | Promoter | Availability | Reference |
|---|---|---|---|---|
tTA-Dependent Responder Lines | ||||
tetO-APP Lines 102 and 107 | mo/huAPP695 (Swe/Ind) | TetO (first generation TRE from pTet-Splice) | MMRRC 34845-JAX, 34846-JAX | [69] |
rTg4510 | huMAPT4R0N (P301L) | TRE (first generation TRE from pTRE) | JAX 015815, 024854 | [29] |
rTg21221 | huMAPT4R0N (wt) | TRE (first generation TRE from pTRE) | Karen Ashe | [156] |
rTg9191 | huAPP695 (Swe/Lon) | TRE (first generation TRE from pTRE) | Karen Ashe | [155] |
hTau-A152T Line L1 | huMAPT4R1N (A152T) | TRE-Tight (second generation TRE) | JAX 028979 | [157] |
hTau-WT Line L32 | huMAPT4R1N (wt) | TRE-Tight (second generation TRE) | JAX 029269 | [157] |
tTA-Expressing Driver Lines | ||||
Camk2a-tTA Line B | tTA (first generation) | moCamk2a | JAX 007004, 003010 | [146] |
EC-tTA | tTA2 (second generation) | Nop/Klk8 | MMRRC 031779-MU | [30] |
NEFH-tTA Line 8 | tTA (first generation) | human NEFH | JAX 025397 | [147] |
ROSA:LNL:tTA | optimized/modified tTA (mtTA) | ROSA26-LNL (Cre-dependent)a | JAX 011008 | [148] |
ROSA26-ZtTA | tTA (first generation) | ROSA26-CAG-LβL (Cre-dependent)b | JAX 012266 (see also 024107) | [149] |