TY - JOUR AU - Yun, Seung Pil AU - Kim, Donghoon AU - Kim, Sangjune AU - Kim, SangMin AU - Karuppagounder, Senthilkumar S. AU - Kwon, Seung-Hwan AU - Lee, Saebom AU - Kam, Tae-In AU - Lee, Suhyun AU - Ham, Sangwoo AU - Park, Jae Hong AU - Dawson, Valina L. AU - Dawson, Ted M. AU - Lee, Yunjong AU - Ko, Han Seok PY - 2018 DA - 2018/01/08 TI - α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism JO - Molecular Neurodegeneration SP - 1 VL - 13 IS - 1 AB - Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibility of nigrostriatal dopamine (DA) neurons in L444P GBA heterozygous knock-in (GBA+/L444P) mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a selective dopaminergic mitochondrial neurotoxin. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-017-0233-5 DO - 10.1186/s13024-017-0233-5 ID - Yun2018 ER -