Fig. 2

Hippocampal proteome analysis of ADLP model mice. a Graphical illustration of the workflow used for our TMT-based proteomic analysis. The detailed sample assignments for TMT labeling are shown in Fig. S2A. b A total of 9814 protein groups were identified in our study; of them, 7022 protein groups were identified and quantified in all experimental sets. The “Not quantified” proteins were identified via search algorithm, but their reporter ions were not detected and were excluded from subsequent quantitative analysis. c A bar chart showing the number of proteins identified in the hippocampus of each ADLP model. d Dynamic range of protein abundance, spanning six orders of magnitude. Normalized reporter ion intensities of pooled samples in each experimental set were used. Proteins known as AD risk factors are annotated in the plot